Endocrine Abstracts

Surgery followed by 131I ablative therapy (IAT) is the usual treatment for patients with differentiated thyroid carcinoma (DTC). Thyroglobulin levels obtained 9–12 months after IAT under TSH stimulation (Tg2) is a very reliable marker for the presence of thyroid tissue. The value of stimulated thyroglobulin previous to ablation (Tg1) is more controversial. The aim of this study was to examine the relationship between Tg1 and Tg2.Material ...

Introduction: When facing with non-functioning pituitary macroadenomas (NFPMA), radiological invasion is determinant to surgical approach, apart from histological biomarkers of pituitary tumor aggressiveness (Ki-67; p53 and mitotic index). Invasive tumors usually need additional surgery and/or radiotherapy. There are no much studies describing epidemiological data on aggressive pituitary tumors in clinical practice. We provide information regarding the radiological findings of...

Fine-needle aspiration cytology (FNAC) remains the mainstay in the study of thyroid nodules, with cytologic adequate specimens in almost 85% of cases in expert hands. Apart from the limitation of inadequate samples, there are false negative diagnoses in some cases, particularly in larger (>3 cm) nodules. Considering this, Large-needle biopsy (LNB) could be useful to improve diagnostic precision. We review the pathology reports (PR) of more than 100 patients operated since ...

Introduction: Maternal clinical thyroid disorders can cause reproductive complications. However, the effects of mild thyroid dysfunction are controversial. The impact of SH and thyroid autoimmunity on miscarriages, obstetric and perinatal outcomes are not yet well established and the effect of levothyroxine replacement in pregnant women with SH is unclear. The aim of this study was to evaluate the impact of thyroid autoimmunity in early pregnancy on obstetric and perinatal out...

Introduction: To date, benign thyroid nodules complainig of symptomatic or cosmetic problems and autonomous functioning thyroid nodules (AFTN) have generally been treated with surgery or I131. Radiofrequency ablation (RFA) is a novel technique that has demonstrated safety and efficacy in the treatment of these nodules. We describe the clinical experience at our hospital.Material and method: We include 33 patients (28 women, 5 men) from January 2013 to Se...

Introduction: Intraoperative parathyroid hormone assay (ioPTH) has been validated as a useful tool for predicting postoperative hypocalcaemia (hypoCa) after thyroid surgery and has been proposed as a guide to early discharge from hospital. Its value to predict the risk of future hypoparathyroidism (hypoPT) has not been analyzed in detail. We evaluate this role in our recent surgical series.Description of methods/design: Patients with total thyroidectomy ...

Introduction: Minimally invasive surgery has become the standard surgical procedure in Primary Hyperparathyroidism (PHP). Targeted parathyroidectomy is associated with a shorter operative duration, a lower risk of complications and a greater patient satisfaction. This approach is dependent on precise localization of the abnormal gland. 99mTc-sestamibi scintigraphy and ultrasonography are acceptable imaging modalities to detect parathyroid adenoma prior to operation but discrep...